Prevention and management of anticancer drug toxicity

the significance of clinical pharmacokinetics
  • 130 Pages
  • 3.57 MB
  • English
Univ.-Verlag , Jena
Antineoplastic agents -- Side effects, Cancer -- Adjuvant treatment, Cancer -- Chemotherapy -- Complications, Pharmacokin
StatementH.-P. Lipp
LC ClassificationsRM301.5 .L56 1995
The Physical Object
Paginationvii, 130 p. :
ID Numbers
Open LibraryOL16004751M
ISBN 103860070843

Anticancer Drug Toxicity: Prevention, Management, and Clinical Pharmacokinetics Nevena Damjanov 1 Modern Pathology vol Cited by: 1. Anticancer Drug Toxicity: Prevention, Management, and Clinical Pharmacokinetics: Medicine & Health Science Books @ ed by: This paper gives an overview of different toxicities of anticancer drugs and its management.

[Int J Basic Clin Pharmacol ; 1(): ] Discover the world's research. Get this from a library. Anticancer drug toxicity: prevention, management, and clinical pharmacokinetics. [Hans-Peter Lipp;] -- "Containing the latest findings on the toxicity of a wide range of chemotherapeutic agents, this up-to-the-minute reference offers expert analyses on the pharmacokinetic-pharmacodynamic and.

Anticancer Drug Toxicity by Hans-Peter Lipp,available at Book Depository with free delivery : Hans-Peter Lipp.

Description Prevention and management of anticancer drug toxicity PDF

Genre/Form: Electronic books: Additional Physical Format: Print version: Anticancer drug toxicity. New York, NY: M. Dekker, © (DLC) Drug-induced cardiotoxicity is an important cause of attrition of compounds in preclinical and clinical development. It represents one of the most serious side effects associated with novel drug development, and it is known to be one of the major toxic effects induced by several types of drugs [].Cardiotoxicity is not restricted to anticancer agents, and almost all therapeutic drug Author: Mina T.

Kelleni, Mahrous Abdelbasset. Anticancer Drug Toxicity: Prevention, Management, and Clinical Pharmacokinetics Lipp Containing the latest findings on the toxicity of a wide range of chemotherapeutic agents, this up-to-the-minute reference offers expert analyses on the pharmacokinetic-pharmacodynamic and pharmacokinetic-toxicodynamic relationships of anticancer compounds.

Drug induced disease is defined as the unintended effect of a drug that results in mortality or morbidity with symptoms sufficient to prompt a patient.

Drug toxicity can develop at normal therapeutic doses of a drug or as a result of an acute overdose. In some cases, toxicity occurs in the majority of treated individuals because of the nature of the drug (e.g.

cytotoxic agents used for cancer chemotherapy), but significant toxicity is rare with the majority of commonly prescribed drugs when.

Anticancer Treatments and Cardiotoxicity is an essential reference for those involved in the research and treatment of cardiovascular toxicity.

Show less Anticancer Treatments and Cardiotoxicity: Mechanisms, Diagnostic and Therapeutic Interventions presents cutting edge research on the adverse cardiac effects of both radiotherapy and. 1. TOXICITY OF ANTI CANCER DRUGS AND ITS AMELIORATION Dr.

Jaya Dadhich Resident, Department of Pharmacology SMS medical college, Jaipur 2. Overview • Anticancer drug target • Toxicities caused by anticancer drugs • Management of individual toxicity • Generalised approach • pharmacological intervention • Summary 3. Abstract.

The use of chemotherapy has largely improved the prognosis of cancer patients in the past two decades. However, the advent of more effective anticancer therapies has led to a higher incidence of cardiovascular toxicity that shows an increased incidence and represents a significant determinant of quality of life and mortality during ongoing treatment Author: Rosalinda Madonna, Francesca Macaione, Peter Ferdinandy.

Mitochondrial dysfunction often underlies drug-induced toxicity and the works published over the last years point out that some of the severe adverse effects promoted by anticancer agents involve the targeting of mitochondria [].

The heart, the kidneys, and the central nervous system, which have high energetic demands and are heavily Author: Mariana Ponte Cardoso Ribeiro, Armanda Emanuela Castro eSantos, José Barata Antunes Custódio.

If a viral infection is ruled out, follow drug rechallenge guidelines outlined in the adult management guidelines (below); doses must be adjusted for age and weight. Adults 1. Discontinue all drugs until the reaction resolves 2. Identify the causative drug by rechallenging (restarting) each drug every 4 days according toFile Size: KB.

Drug toxicology focuses on the harmful effects of drugs in the animal and human body. In virtually all respects, the pharmacologic principles discussed in the preceding chap-ters apply to the study of drug toxicity.

Thus, just as drug-receptor interactions are fundamental to understanding theFile Size: KB. Helen F.

Download Prevention and management of anticancer drug toxicity FB2

Lever, Assistant, Drug Information, Drug Management and Authorization Section, Investigational Drug Branch, National Cancer Institute Book 8 was first published in in response to numerous requests from SEER Program Phase I clinical trials assess the pharmacology and dose-limiting toxicity of the drug in Size: 6MB.

Journal of Medical Toxicology Research is an open access peer-reviewed scholarly journal and aims to focus on the diagnosis, management and prevention of toxicity and other adverse health effects due to medications, occupational and environmental substances, and biological agents.

In Journal of Medical Toxicology also includes all aspects of, pharmacokinetics. Author(s): Lipp,Hans-Peter, Title(s): Anticancer drug toxicity: prevention, management, and clinical pharmacokinetics/ edited by Hans-Peter Lipp. Drug Injecting and HIV Infection: global dimensions and local responses, This book is a definitive account of drug injecting behaviour and HIV infection in cities across the world.

The book is based on an important study initiated by WHO inlaunched against a background of the rapid spread of HIV infection in a number of major cities. Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx) is a type of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents) as part of a standardized chemotherapy herapy may be given with a curative intent (which almost always involves combinations of drugs), or it may aim to prolong life or to reduce Other names: chemo.

ONS published extravasation prevention and management guidelines in the book “Chemotherapy and Biotherapy Guidelines and Recommendations for Practice”, Polovich et al (). Examples of guidelines provided are close monitoring of the infusion site every 5 to 10 min and avoiding infusion of vesicants for more than 30 to 60 min[ 1 ].Cited by: The book includes a new chapter on immuno-oncology drugs.

Organised by organ system, it lists the toxicity, side-effects and measures of prevention pertaining to each type of drug used in cancer therapy. The most dangerous side-effects are priority so. Introduces readers to the growing applications of nutraceuticals and other natural product derivatives This comprehensive book presents a prophylactic and therapeutic approach to chronic disease prevention strategy by highlighting the translational potential of plant-derived dietary and non-dietary factors from epidemiological, laboratory, and clinical studies.

It also Format: Hardcover. Inthe Japanese Society of Hospital Pharmacists (Scientific Committee / 1st Subcommittee) created “In-hospital Antineoplastic Drug Handling Guidelines 6) (not for sale)” as the first guidelines in Japan for the prevention of exposure to antineoplastic drugs. Its contents included guidelines and notes for the in-hospital handling of antineoplastic agents, a list of.

Received anticancer therapy, therapy for DTGCT, including investigational therapy, within 2 weeks or 28 days for therapies with half-life longer than 3 days prior to the administration of study drug.

Unresolved toxicity (>Grade 1 or baseline) from previous anticancer therapy, excluding alopecia. Known active CNS metastases. Topics on Drug Metabolism. This book presents some in-depth reviews of selected topics in drug metabolism.

Topics covered includes: Oral Absorption, Intestinal Metabolism and Human Oral Bioavailability, Pharmacogenetics and Metabolism, Altered Drug Metabolism and Transport in Pathophysiological Conditions, Anticancer Drug Metabolism: Chemotherapy Resistance and.

Read Quantitative Structure-Activity Relationships for Pollution Prevention Toxicity Screening. A drug used in the emergency treatment of patients who receive too much fluorouracil or capecitabine (types of anticancer drugs).

It is also used in the emergency treatment of heart or central nervous system (CNS) toxicity or other serious side effects that occur within 4 days of ending treatment with fluorouracil or capecitabine. parallel-opposed fields provoked substantial acute toxicity, which included painful desquamation of inguinal and perianalskin, diarrhea, and a loss ofbone marrow : Cathy Eng, Craig Messick, Rob Glynne-Jones.

Title:Interactions of Cisplatin with non-DNA Targets and their Influence on Anticancer Activity and Drug Toxicity: The Complex World of the Platinum Complex VOLUME: 14 ISSUE: 9 Author(s):Roman Mezencev Affiliation:School of Biology, Georgia Institute of Technology, Ferst Drive, Atlanta, GAUSA.

Details Prevention and management of anticancer drug toxicity PDF

Keywords:Ap4A, BRCA1, cisplatin, glutathione, Cited by: This unique book provides an overview of the anticancer herbal medicines and remedies, as well as a detailed evidence-based evaluation of 18 common anticancer herbal medicines covering their biological and pharmacological properties, efficacies, herb-drug interactions, adverse effects, pre-clinical studies, and clinical applications.Anticancer drug renal toxicity and elimination: dosing guidelines for altered renal function.

Cancer Treat Rev ; Gerber DE, Grossman SA, Batchelor T, Ye X. Calculated versus measured creatinine clearance for dosing methotrexate in the treatment of primary central nervous system lymphoma.